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KMID : 0380420150390020048
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Journal of Prventive Veterinary Medicine
2015 Volume.39 No. 2 p.48 ~ p.57
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Distribution and accumulation of Cy5.5-labeled hydrophobically modified glycol chitosan in mice
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Lee Jung-Su
Ji Hyeong-Jin
Chai Hee-Youl
Jeong Jae-Hwang
Nam Sang-Yoon
Yun Young-Won
Lee Beom-Jun
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Abstract
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The ultimate goal of this study is to assess the accumulation and distribution of hydrophobically modified glycol chitosan (HGC) as a degradable nanoparticle in the body. To understand the movement of degradable nanoparticle HGC in the body, we intravenously injected a dose of 20 mg/kg of Cy5.5-labeled HGC with size ranging from 320 to 400 nm into ICR mice, and measured the amount of fluorescence remaining in blood and several organs at various time intervals. In blood, the level of Cy5.5-labeled HGC increased at 15 min and after 30 min and then decreased gradually and reached a plateau at 28 days. In the tissue we confirmed the presence of nanoparticles at high levels in the order of kidney>liver>submandibular gland until 28 days after injection. However, we did not find the distribution of the particles into brain or testes. These results will provide basic information on HGC as a drug delivery agent.
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KEYWORD
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Cy5.5-labeled hydrophobically modified glycol chitosan, drug delivery agent
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